Due to its unique ‘single-shot’ detection technique, the EasyLife™ L is lightening fast. It can measure up to 500 complete decays in a second. The decays are instantly analyzed in real time enabling the user to follow reaction kinetics by plotting the lanthanide lifetime rather than the intensity as a function of time. This is the basis for a new, unique feature that only EasyLife™ L can offer: the Timebased Lifetime Scan. This makes the experiment immune to artifacts that usually affect intensity, such as light scattering, concentration fluctuations, precipitation etc. The lifetime-based technique is ideal for sensing applications, where binding of a substrate changes the lanthanide lifetime.

• LRET based kinase activity assays
• Conformational changes in ligand-binding glutamate receptor
• Sigma factor binding to RNA polymerase
• K+ channel voltage sensor movement in cell membranes
• Detection of salicylic acid in blood by sensitized Tb luminescence
• Assays for determining antibiotics (norfloxacin, garenoxacin, grepafloxacin) in urine and serum
• DNA-lanthanide assays for multi-drug resistance of TB strains
  

	The binding kinetics of Tb3+ to DNA can be followed free of intensity artifacts by using the unique Timebased Lifetime Scan. Here the EasyLife™ L performs continuous rapid measurements of the average terbium lifetime in real time.
DNA-lanthanide assays are used in a number of diagnostic tests, for example DNA-Tb3+ in testing for antibiotic resistance of tuberculosis strains. Terbium luminescence is enhanced upon binding to DNA, which results in 3 fold increase of Tb3+ lifetime.

• Single-shot operation
• Ideal for LRET assays and phosphorescence
• Ultra-high sensitivity and acquisition speed
• Very high precision
• High stability and reproducibility
• Instant lifetime determination
• Timebased lifetime scan
• Timebased intensity scan
• Lifetime temperature ramping
• Intensity temperature ramping
• Reduced bleaching
• Low maintenance

• Manual sheet polarizers
• Liquid nitrogen dewar
• Rotatable solid sample holder
• Rotatable powder sample holder
• Bandpass filters
• Long-pass filters
• Neutral density filters
• Microcuvette with adapter